报告人介绍：Adamstudied chemistry at the University of Nottingham (MSci, 2004-2008) beforecompleting his PhD with Prof. Jim Anderson at University College London(2008-2012). This was followed by postdoctoral positions with Prof. DaveMacMillan at Princeton University (2012-2014) and Prof. Varinder Aggarwal atthe University of Bristol (2014-2017). He then worked as the Research Officerin the Aggarwal group before beginning his independent research at theUniversity of Bristol in 2022, where he is currently a Lecturer in the Schoolof Chemistry. His research interests focus on methodology development usingvisible light photochemistry. He has published over 60 papers in top journalssuch as Nature, Nat. Syn., J. Am. Chem. Soc., Angew. Chem. Int. Ed., etc.
报告摘要：Ketyl radicals are valuableintermediates that allow carbonyl chemistry to be extended beyond traditionalelectrophilic reactivity. However, accessing ketyl radicals by single-electronreduction of carbonyls requires strongly reducing conditions. This talk willfocus on our development of an alternative strategy to access ketyl radicalsfrom aldehydes that avoids the reduction pathway, instead proceeding viasingle-electron oxidation and desulfination of in situ-generated α-hydroxy sulfinates.Furthermore, our recent discovery of simple photochemical conditions forcarbonyl–olefin couplings via alkene radicalanion intermediates will be discussed.
