杨光

杨光教授

杨光，博士，生物与医学工程学院教授。2009年于浙江大学获得工学博士学位，美国加州大学洛杉矶分校生物工程系、美国北卡罗来纳大学教堂山分校生物医学工程系访问学者。长期从事生物医用材料、经皮药物递送方向的基础和应用研究。主持国家自然科学基金面上项目、上海市自然科学基金等研究课题10余项；以通讯/第一作者在Advanced Materials、ACS Nano、Advanced Functional Materials等学术期刊发表论文40余篇；申请中国发明专利20余项及PCT国际专利1项。

研究方向：

1. 角蛋白基水凝胶及其在糖尿病创面修复中的应用

2. 经皮药物递送系统及其在皮肤相关疾病中的应用

荣誉及获奖情况：

1. 2019年入选上海市浦江人才计划

2. 2011年入选上海市晨光人才计划

近年来承担的主要项目情况：

1. 双层水凝胶时序调控炎症细胞行为促进糖尿病创面修复的作用与机制研究，国家自然科学基金面上项目

2. 可控透皮给药治疗类风湿关节炎及其减毒增效作用评价，上海市自然科学基金项目

3. 微针介导胺碘酮局部长效给药治疗心脏术后房颤，上海市科委浦江人才计划项目

4. PLGA基储库微针用于心房局部长效给药的研究，聚合物分子工程国家重点实验室（复旦大学）开放研究课题基金

5. 角蛋白矿化制备高荧光纳米金簇及汞离子检测应用，中国博士后科学基金项目（一等）

6. 基于生物模板效应的BC/AgNPs功能复合材料的设计合成及性能研究，国家自然科学基金青年基金项目

7. 生物纳米纤维基小径血管的构建及其性能研究，上海市自然科学基金项目

8. 细菌纤维素基功能医用纳米材料的绿色合成及应用基础研究，上海市教育委员会“晨光计划”项目

9. 载银纳米纤维敷料的生物相容性研究，上海市教委“上海高校青年教师培养资助计划”项目

近年来发表的代表性论著：

论文

1. Cui Mingrui; Wang Wenshuo; Han Xiaoyue; Lu Ziyi; Yang Xuexia; Liu Lingyan; Zhou Xiaojun; Chen Shuo; Wei Lai; Chen Nan; He Chuanglong*; Yang Guang*, Designing Microneedle Patch for Prophylaxis of Postoperative Atrial Fibrillation. ACS Nano, 2024 18 (29), 18889-18899

2. Wang Wenshuo; Chen Yansong; Huang Liqi; Lu Ziyi; Muhammad Asad Ullah; Wei Lai; Yang Guang*, Reservoir Microneedle Patch Mitigates Postsurgical Atrial Fibrillation. Advanced Functional Materials, 2024, 231252.

3. Lu Ziyi; Du Shan; Li Jiaxun; Zhang Min; Nie Huali; Zhou Xiaojun; Li; Fulun; Wei Xinwei; Wang Jinqiang; Liu Fuyao; He Chuanglong*; Yang Guang*; Gu Zhen*, Langmuir–Blodgett-Mediated Formation of Antibacterial Microneedles for Long-Term Transdermal Drug Delivery. Advanced Materials, 2023, 2303388.

4. Shi Tongtong; Lu Hanzhi; Zhu Jianyong; Zhou Xiaojun; He Chuanglong*; Li Fulun*; Yang Guang*; Naturally derived dual dynamic crosslinked multifunctional hydrogel for diabetic wound healing, Composites Part B-Engineering, 2023, 257, 110687.

5. Chen Yansong; Li Ying; Yang Xuexia; Cao Zhangjun; Nie Huali; Bian Yonggang; Yang Guang*; Glucose-triggered in situ forming keratin hydrogel for the treatment of diabetic wounds, Acta Biomaterialia, 2021, 125: 208-218.

6. Du Shan; He Tiantian; Nie Huali*; Yang Guang*; High-performance wigs via the Langmuir–Blodgett deposition of keratin/graphene oxide nanocomposite, ACSApplied Materials & Interfaces, 2022, 14: 27233-27241.

7. Tang Ao; Li Ying; Yao Yiqian; Yang Xuexia; Cao Zhangjun; Yang Guang*；Injectable keratin hydrogels as hemostatic and wound dressing materials, Biomaterials Science, 2021,9:4169-4177.

8. Yang Guang; Chen Qian; Wen Di; Chen Zhaowei; Wang Jinqiang; Chen Guojun; Wang Zejun; Zhang Xudong; Zhang Yuqi; Hu Quanyin; Zhang Liang*; Gu Zhen*; A therapeutic microneedle patch made from hair-derived keratin for promoting hair regrowth, ACS Nano, 2019, 13: 4354-4360.

9. Li Ying; Cao Yu; Wei Lai; Wang Jinjie; Zhang Min; Yang Xuexia; Wang Wenshuo; Yang Guang*; The assembly of protein-templated gold nanoclusters for enhanced fluorescence emission and multifunctional applications, Acta Biomaterialia, 2020, 101: 436-443.

10. Cao Yu; Yao Yiqian; Li Ying; Yang Xuexia; Cao Zhangjun; Yang Guang*; Tunable keratin hydrogel based on disulfide shuffling strategy for drug delivery and tissue engineering,Journal of Colloid and Interface Science, 2019, 544: 121-129.

11. Li Yan; Song Kai; Cao Yu; Peng Chen*; Yang Guang*; Keratin-templated synthesis of metallic oxide nanoparticles as MRI contrast agents and drug carriers, ACS Applied Materials & Interfaces, 2018, 10: 26039-26045.

12. Chen Qian; Wang Chao; Zhang Xudong; Chen Guojun; Hu Quanyin; Li Hongjun; Wang Jinqiang; Wen Di; Zhang Yuqi; Lu Yifei; Yang Guang; Jiang Chen; Wang Jun; Dotti Gianpietro; Gu Zhen*; In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment, Nature Nanotechnology, 2019,14: 89-97.

13. Wang Jinjie; Ma Shuyi; Ren Jicun; Yang Jinxia; Qu Yi; Ding Derun; Zhang Min*; Yang Guang*; Fluorescence enhancement of cysteine-rich protein-templated gold nanoclusters using silver(I) ions and its sensing application for mercury(II), Sensors and Actuators B: Chemical, 2018,267: 342-350.

14. Yang Guang*; Wang Caixia; Hong Feng*; Yang Xuexia; Cao Zhangjun; Preparation and characterization of BC/PAM-AgNPs nanocomposites for antibacterial applications, Carbohydrate Polymers, 2015, 115: 636-642.

15. Yang Guang*; Xie Jianjian; Hong Feng; Cao Zhangjun; Yang Xuexia; Antimicrobial activity of silver nanoparticle impregnated bacterial cellulose membrane: Effect of fermentation carbon sources of bacterial cellulose, Carbohydrate Polymers, 2012, 87: 839-845.

16. Yang Guang*; Xie Jianjian; Deng Yunxia; Bian Yonggang; Hong Feng; Hydrothermal synthesis of bacterial cellulose/AgNPs composite: A “green” route for antibacterial application, Carbohydrate Polymers, 2012, 87: 2482-2487.

E-MAIL：gyang@dhu.edu.cn