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莫秀梅


莫秀梅教授

莫秀梅,1961年12月生。生物材料与组织工程学科教授、博士生导师。莫秀梅教授归国前曾为日本京都大学博士后,新加坡国立大学研究员,日本関西産業技術総合研究所客座研究员,德国亚琛工业技术应用大学客座教授。现为东华大学生物医学工程学科“生物材料与组织工程” 课题组组长。为新加坡材料协会会员,中国生物医学工程学会生物材料分会委员,“Frontiers of Materials Science”杂志编委。





研究方向:

生物材料,纳米纤维,组织工程,再生医学。

1、静电纺纳米纤维在生物医学中的应用,包括小血管、神经、皮肤、骨和软骨等组织的再生,药物及活性物质的缓释

2、新型生物材料的研究开发,包括医用水凝胶,可降解聚合物的合成及应用研究

3、三维快速成型制备组织工程支架及在骨和软骨再生中的应用

主要研究成果:

1、制备出蛋白-多糖双组份医用胶粘合剂

2、制备出蛋白-多糖复合纳米纤维并成功地用于大鼠的皮肤缺损修复

3、制备出丝素-P(LLA-CL)复合纳米纤维导管并成功地用于大鼠的坐骨神经修复

4、制备出胶原蛋白-壳聚糖-P(LLA-CL)复合纳米纤维管状支架并成功地用于狗的股动脉缺损的修复

5、已发表文章及会议论文200多篇,申请专利20多项,获权专利7项

荣誉及获奖情况:

1、首届浦江人才

2、2008桑麻科教奖

3、2008上海市技术发明一等奖“水溶性医用几丁糖的制备技术及应用”

4、2009国家科技进步二等奖“水溶性几丁糖医用制品的研制及临床应用”

5、2009-2010年度东华大学“三八”红旗手


近几年主持的科研项目:

1、国家自然科学基金:甲壳素的结构性能及应用研究

2、国家自然科学基金:PEG接枝壳聚糖的备及性能研究

3、国家自然科学基金: 胶原蛋白-甲壳胺复合纳米纤维仿生组织细胞间质及与细胞相互作用的研究

4、国家自然科学基金:小口径血管的体内再生研究

5、国家高技术研究发展863计划纳米材料与器件专题:蛋白-多糖复合纳米纤维用于组织修复的研究

6、教育部归国留学人员基金: 纳米纤维的制备表征及在组织工程中的应用开发

7、上海市2005年重大基础研究课题子课题: 组织工程相关生物材料的基础科学问题研究 中的小血管组织工程再建

8、上海市白玉兰科技人才基金:小口径血管组织再生的研究

9、上海市科委非政府国际合作项目: 控释型活性纳米纤维神经导管及心脏瓣膜的研制

10、上海市科委纳米专项:纳米纤维仿生材料用于组织修复的研究

11、上海市科委纳米专项:蛋白-多糖-P(LLA-CL)复合纳米纤维用于小血管组织再生


近三年发表论文:

1、Chun-Yang Wang,Jun-Jian Liu,Cun-Yi Fan,Xiu-Mei Mo,Hong-Jiang Ruan,Feng-Feng Li, The Effect of Aligned Core-Shell Nanofibres Delivering NGF on the Promotion of Sciatic Nerve Regeneration, Journal of Biomaterials Science, Polymer Edition, 23(1-4), 2012 , 167-184

2、Yan Su, Qianqian Su, Wei Liu, Marcus Lim, Jayarama Reddy Venugopal, Xiumei Mo, Seeram Ramakrishna, Salem S. Al-Deyab, Mohamed El-Newehy, Controlled release of bone morphogenetic protein 2 and dexamethasone loaded in core–shell PLLACL–collagen fibers for use in bone tissue engineering, Acta Biomaterialia 2012, 8, 763–771

3、LinpengFan,Hongsheng Wang, Kuihua Zhang, Chuanglong He, Zengxiao Cai, Xiumei Mo, Regenerated Silk Fibroin Nanofibrous Matrices Treated with 75% Ethanol Vapor for Tissue-Engineering ApplicationsJournal of Biomaterials Science, Polymer Edition, 2012, 23, 497-508

4、余丕军,王露萍,郭妤,陈炜,莫秀梅, 胶原蛋白-壳聚糖复合纳米纤维膜用于皮肤缺损的修复, 中国组织工程研究与临床康复, 2011, 15(51):9561-9564

5、Chen Huang, Yanwei Tang, Xin Liu, Alessandra Sutti, Qinfei Ke, Xiumei Mo, Xungai Wang, Yosry Morsi and Tong Lin. Electrospinning of nanofibres with parallel line surface texture for improvement of nerve cell growth. Soft Matter, 2011, 7, 10812-7

6、Kuihua Zhang, Anlin Yin, Chen Huang, Chunyang Wang, Xiumei Mo. Degradation of electrospun SF/P(LLA-CL) blended nanofibrous scaffolds in vitro. Polymer Degradation and Stability2011 96: 2266-75

7、A Owida, Rui Chen, S Patel, Yos Morsi, Xiumei Mo. Artery vessel fabrication using the combined fused deposition modeling and electrospinning techniques. Rapid Prototyping Journal. 2011;17:37-44

8、Cuanglong He, Xiaohong Xu, Fan Zhang, Lijun Cao, Wei Feng, Hongsheng Wang, Xiumei Mo. Fabrication of fibrinogen/P(LLA-CL) hybrid nanofibrous scaffold for potential soft tissue engineering applications. Journal of Biomedical Materials Research Part A. 2011;97A:339-47

9、Kuihua Zhang, Q-Z Yu, XiumeiMo.Fabrication and Intermolecular Interactions of Silk Fibroin/Hydroxybutyl Chitosan Blended Nanofibers. International Journal of Molecular Sciences. 2011;12:2187-99

10、Kuihua Zhang, Yongfang Qian, Hongsheng Wang, Lingpen Fan, Chen Huang, Xiumei Mo. Electrospun Silk Fibroin-Hydroxybutyl Chitosan Nanofibrous Scaffolds to Biomimic Extracellular Matrix. Journal of Biomaterials Science-Polymer Edition. 2011;22:1069-82

11、Fan Zhang, Chuanglong He, Lijun Cao, Feng W, Wang H, Mo X, et al. Fabrication of gelatin-hyaluronic acid hybrid scaffolds with tunable porous structures for soft tissue engineering. International Journal of Biological Macromolecules. 2011;48:474-81

12、Feng Chen, Ying-Jie Zhu, Kui-Hua Zhang, Jin Wu, Ke-Wei Wang, Qi-Li Tang, XiumeiMo.Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers, Nanoscale Research Letters2011, 6:67

13、Yan Su, Xiaoqiang Li, Yinan Liu, Qianqian Su, Marcus Lim,Wei Qiang and Xiumei Mo,Encapsulation and Controlled Release of Heparin from Electrospun Poly(L-Lactide-co-ε-Caprolactone) Nanofibers, Journal of Biomaterials Science-Polymer Edition. 22 (2011) 165–177

14、Chen Huang, Rui Chen, Qinfei Ke, Yosry Morsic, Kuihua Zhang, Xiumei Mo. Electrospun collagen–chitosan–TPU nanofibrous scaffolds for tissue engineered tubular grafts, Colloids and Surfaces B: Biointerfaces82 (2011) 307–315

15、Yong-Fang Qian, Kui-Hua Zhang, Feng Chen, Qin-Fei Keand Xiumei Mo.Cross-Linking of Gelatin and Chitosan Complex Nanofibers for Tissue-Engineering Scaffolds, Journal of Biomaterials Science22 (2011) 1099–1113

16、Chun-Yang Wang, Kui-Hua Zhang, Cun-Yi Fan, Xiumei Mo, Hong-Jiang Ruan, Feng-Feng Li. Aligned natural–synthetic polyblend nanofibers for peripheral nerve regeneration, Acta Biomaterialia7 (2011) 634–643

17、余丕军,王露萍,郭妤,陈炜,莫秀梅,蛋白质-多糖复合纳米纤维膜用于皮肤缺损修复实验研究,中国医学工程,2010,18(4), 1-4.

18、Feng Chen1, Peng Huang, Xiu-MeiMo.Electrospinning of Heparin Encapsulated P(LLA-CL) Core/Shell Nanofibers,Nano Biomedicine And Engineering 2010,2,84-90

19、Zonggang Chen, Peiwei Wang, B. Wei, Xiumei. Mo, F.Z. Cui. Electrospun collagen–chitosan nanofiber: A biomimetic extracellular matrix for endothelial cell and smooth muscle cell. Acta Biomaterialia. 2010,6,372-382.

20、Kuihua Zhang, Yongfang Qian, Hongsheng Wang, Lingpen Fan, Chen Huang, AnlinYin, Xiumei Mo.Genipin-crosslinked silk fibroin/hydroxybutyl chitosan nanofibrous scaffolds for tissue-engineering application. Journal of Biomedical Materials Research Part A.2010;95A:870-81

21、Xiaoqiang Li, Yan Su, SP Liu, LJ Tan, Xiumei Mo.Ramakrishna S. Encapsulation of proteins in poly(L-lactide-co-caprolactone) fibers by emulsion electrospinning.Colloids and Surfaces B-Biointerfaces. 2010;75:418-24

22、Rui Chen, Qinfei Ke, XiumeiMo. Preparation and Study of TPU/Collagen Complex Nanofiber via Electrospinning. Aatcc Review. 2010;10:59-63

23、XiumeiMo, Hiroo Iwata, Yoshito Ikada. A tissue adhesives evaluated in vitro and in vivo analysis. Journal of Biomedical Materials Research Part A. 2010;94A:326-32

24、Zengxiao Cai, Xiumei Mo, Kui-hua Zhang, Lin-peng Fan, An-lin Yin, Chuang-long He and Hong-sheng Wang, Fabrication of Chitosan/Silk Fibroin Composite Nanofibers for Wound-dressing Applications, Int. J. Mol. Sci. 2010, 11, 3529-3539

25、Kuihua Zhang, Hongsheng Wang, Chen Huang, Yan Su, Xiumei Mo, Yoshito Ikada.Fabrication of silk fibroin blended P(LLA-CL) nanofibrous scaffolds for tissue engineering.J Biomed Mater Res A. 2010, 93(3):984-993

26、Kuihua ZHANG, Xiumei Mo, Chen HUANG, Chuanglong HE, Hongsheng WANG. Electrospun scaffolds from silk fibroin and their cellular compatibility. J Biomed Mater Res A.2010, 93(3): 976-983

27、Cai-jiu Gao, Kui-Hua Zhang, Wei Liu, Xu Zhou, Xiumei Mo. Electrospun Scaffolds from Gelatin/Hyaluronic Acid and their cellular compatibility. Nonlinear Science Letters D, 1, 67-72, 2010

28、Kui-Hua Zhang, Hong-Sheng Wang, Cai-Jiu Gao, Lin-Peng Fan, XiumeiMo.Fabrication of Electrospinning Silk Fibroin and its blend nanofibrous Scaffolds for Soft Tissue Engineering. Nonlinear Science Letters D, 1, 53-58, 2010

29、Rui Chen, Xiaoqiang Li, Qinfei Ke, Chuanglong He, Xiumei Mo. Fabrication and characterization of collagen (shell) /thermoplastic polyurethane (core) composite nanofibers by coaxial electrospinning. e-Polymers,2010, No009: 1-8

30、Rui Chen, Chen Huang, Qinfei Ke, Chuanglong He, Hongsheng Wang, Xiumei Mo. Preparation and Characterization of Coaxial Electrospun Thermoplastic Polyurethane/Collagen Compound Nanofibers for Tissue Engineering Applications. Colloids and Surfaces B: Biointerfaces.2010, 79,315-325

31、Rui Chen,Lijun Qiu, Qinfei Ke, and XiumeiMo.Electrospinning Thermoplastic Polyurethane-contained Collagen Nanofibers for Tissue Engineering Applications. Journal of Biomaterials science: Polymer Edition,2009, 20(11): 1513-36

32、R. Chen,Y. Morsi, A. Owida, X.M Moand Q.F Ke. Electrospinning of Thermoplastic Polyurethane Tubular Scaffold For The Construction of Artificial Blood Vessels.International Journal of Artificial Organ, 2009 July, 32(7): 459

33、Rui Chen, Qinfei Ke, XiumeiMo.Preparation and Study of TPU-Collagen Complex Nanofiber via Electrospinning. AATCC Review, March/April, 2010, 59-66

34、Rui CHEN,Yosry MORSI, Shital PATEL, Qinfei KE, Xiumei MONovel Approach via Combination of Electrospinning and FDM for Tri-leaflet Heart Valve Scaffold Fabrication. Frontier Materials Science of China.2009,3(4):359-366

35、Yan Su, Xiaoqiang Li, Hongsheng Wang, Chuanglong He, and Xiumei Mo. Fabrication and Characterizations of Biodegradable Nanofibrous Mats by Mix and Coaxial Electrospinning of Poly(L-lactid-co-ε-caprolactone). Journal of Materials Science: Materials in Medicine. 2009 C, 2009, 20:2285–2294

36、Yan Su, Xiaoqiang Li , Suiping Liu, XiumeiMoand Ram Seeram. Controlled Release of Dual drugs from Emulsion Electrospun Nanofibrous Mats. Colloids and interfaces B: Biointerfaces, 2009, 73 (2): 376-381

37、Yan Su, Xiaoqiang Li, Lingjiang Tan Cheng Huang, XiumeiMo.Electrospun Poly(L-lactide-co-ε-caprolactone) nanofibers for encapsulating and sustained releasing proteins. Polymer. 2009, 17 (50): 4212-4219

38、Yongfang Qian, Xiaoqiang Li, Xiumei Mo. Fabrication and characterization of Polycaprolactone/Chlorophyllin sodium copper salt nanofibrous mats from 2,2,2-trifluoroethanol solution by electrospinning. Iranian Polymer Journal. 2009, 18(3): 265-274

39、Zonggang Chen, Bo Wei, Xiumei Mo, Fu-zhai Cui. Diameter Control of Electrospun Chitosan-Collagen Fibers.Polym. Sci Part B: Polym. Phys.2009, 47:1949-1955

40、Zonggang Chen, Bo Wei, Xiumei Mo, C.T. Lim, S. Ramakrishna, Fuzhai Cui. Mechanical properties of electrospun collagen–chitosan complex single fibers and membrane. Materials Science and Engineering C. 2009, 29:2428–2435

41、Xiaoqiang Li, Yan Su, Xu Zhou and XiumeiMo.Distribution of Sorbitan Monooleate in poly(l-lactide-co-caprolactone) nanofibers from emulsion electrospinning. Colloids and Surfaces B: Biointerfaces,2009, 69: 221-224

42、Huihua Huang, Chuanglong He, Hongsheng Wang, XiumeiMo.Preparation of Core-shell Biodegradable microfibers for long-term Drug delivery.J Biomed Mater Res A2009, 90A(4):1243–1251

43、Xiaoqiang Li, Yan Su, Chuanglong He, Hongsheng Wang, and XiumeiMo.A Study of the Electrospinning of an H2O–Acetone–PCL Ternary System. Polymers & Polymer Composites, 2009, 17(1) : 37-40

44、Xiaoqiang Li, Yan Su, Rui Chen, Chuanglong He, Hongsheng Wang, Xiumei Mo. Fabrication and Properties of Core-Shell Structure P(LLA-CL) Nanofibers by Coaxial Electrospinning. J Appl Polym Sci, 2009,111: 1564–1570

45、Xiaoqiang Li, Yan Su, Chuanglong He, Hongsheng Wang, Fong Hao, and Xiumei Mo. Sorbitan Monooleate and Poly(L-lactide-co-ε-caprolactone) Electrospun Nanofibers for Endothelial Cell Interactions. J Biomed Mater Res A. 2009, Dec 1, 878-885

46、Feng Chen, Yan Su, Xiumei Mo, et al, Biocompatibility, Alignment Degree and Mechanical Properties of an Electrospun Chitosan-P(LLA-CL) Fibrous Scaffold,Journal Of Biomaterials Science-Polymer Edition20(14)2117-2128,2009

47、张鹏云,张建松,徐晓红,莫秀梅,何创龙, 生物交联剂京尼平对静电纺明胶纳米纤维膜改性的影响。中国组织工程研究与临床康复. 13(8),1495-99,2009

48、张建松,张鹏云,徐晓红,莫秀梅,何创龙,王红声, 两种聚(左选乳酸-己内酯)静电纺纳米纤维膜的性能比较。中国组织工程研究与临床康复. 13(8),1500-04,2009。

49、邱立军 , 王红声 , 何创龙 , 莫秀梅。聚(左旋乳酸-己内酯)/Fe304取向超细纤维的制备及生物相容性。中国组织工程研究与临床康复.13(12),2222,2009

国际交流与合作:

目前与新加坡国立大学(National University of Singapore),美国弗吉尼亚联邦大学(Virginia Commonwealth University),澳大利亚斯文伯恩技术大学(Swinburne University of Technology),日本奈良医科大学(Nara Medical University),澳大利亚迪肯大学(Deakin University),沙特国王大学(King Saud University) 有合作科研和教学。

联系电话:021-67792653          EMAIL:xmm@dhu.edu.cn