返回教授名录

何创龙


何创龙教授

何创龙1971年出生。东华大学化学化工与生物工程学院生物工程系,教授,博士生导师。重庆大学生物医学工程专业博士,同济大学和密歇根大学(公派)博士后。近年来主持或作为主要成员参与完成国家863计划、国家自然基金、教育部和上海市科委等科研项目20余项;共发表期刊论文140多篇,SCI引用1700多次;发表国际会议论文70多篇;出版译著一本;申请中国发明专利56项,获授权21项;2015年获上海市自然科学三等奖一项;系美国化学会、中国化学会、中国生物材料学会、中国生物医学工程学会会员;任上海市生物材料专业委员会委员,广东省医学生物力学重点实验室学术委员会委员;担任80多个国际期刊的审稿人;任科技部国家重点研发计划、国家自然科学基金和上海市科委项目评审专家。


研究方向:

1. 生物材料、组织工程、纳米医学;

2. 有机/无机杂化材料与自组装生物材料;

3. 环境响应性药物控释材料;

4. 生物纳米材料及仿生修复材料。

荣誉及获奖情况:

上海市科学技术奖自然科学三等奖(2015年)

近年主持的省部级以上科研项目:

1. 国家自然科学基金面上项目(31570984), 促血管祖细胞募集的小口径血管支架构建与原位再生研究, 2016.1-2019.12

2. 国家自然科学基金面上项目(31271028),双因子程序释放的骨支架构建及促血管化和成骨活性研究, 2013.1-2016.12

3. 上海市科委国际科技合作项目(15540723400), 石墨烯基纳米骨支架的构建及其在骨缺损治疗中的应用, 2015.10-2018.9

4. 上海市教委科研创新重点项目(13ZZ051), 外场作用下的电化学协同沉积与仿生骨支架研究, 2013.1-2015.12

5. 上海市自然科学基金(11ZR1400100), 纳米纤维的电化学协同自组装修饰及具有血管化潜能的骨支架研究, 2011.4.1-2014.3.31

6. 上海市自然科学基金(07ZR14001), 纤维蛋白纳米纤维组织工程血管的基础研究, 2007.12-2009.11

7. 上海市科委纳米科技项目(11nm0505500), 具有诱导血管生成和成骨活性的纳米纤维骨修复材料研究, 2011.11-2014.9

8. 教育部留学回国人员科研启动基金, 具有促血管化潜能的复合纳米纤维骨支架的研究, 2012.1-2014.12

9. 教育部博士点基金(200802551014), 纳米纤维的电化学仿生矿化及用于骨支架材料的研究, 2009.1-2011.12

10. 上海市白玉兰科技人才基金(2010B001),有机/无机复合骨组织工程支架的研究, 2010.6-2011.5

近年发表的代表性学术论文:

1. Nie W, Peng C, Zhou XJ, Chen L, Wang WZ, Zhang YZ, Ma PX*, He CL*. Three-dimensional porous scaffold by self-assembly of reduced graphene oxide and nano-hydroxyapatite composites for bone tissue engineering. Carbon. 2017; 126: 325-337.

2. Li DJ, Nie W, Chen L, Miao YK, Zhang X, Chen FC, Yu B, Ao RG, Yu BQ*, He CL*. Fabrication of curcumin-loaded mesoporous silica incorporated polyvinyl pyrrolidone nanofibers for rapid hemostasis and antibacterial treatment. RSC Adv. 2017; 7: 7973-7982.

3. Weng WZ, Nie W, Zhou QR, Zhou XJ, Cao LH, Ji F*, Cui J, He CL*, Su JC*. Controlled release of vancomycin from 3D porous graphene-based composites for dual-purpose treatment of infected bone defects. RSC Adv. 2017; 7: 2753-2765.

4.Chen L, Zhou XJ, Nie W, Zhang QQ, Wang WZ, Zhang YZ, He CL*. Multifunctional redox-responsive mesoporous silica nanoparticles for efficient targeting drug delivery and magnetic resonance imaging. ACS Appl. Mater. Interfaces. 2016, 8 (49), 33829-33841.

5. Zhou XJ, Chen L, Nie W, Wang WZ, Qin M, Mo XM, Wang HS, He CL*. Dual-responsive mesoporous silica nanoparticles mediated co-delivery of doxorubicin and Bcl-2 siRNA for targeted treatment of breast cancer. J. Phys. Chem. C. 2016; 120(39): 22375-22387.

6. Chen L, Feng W, Zhou XJ, Qiu KX, Miao YK, Zhang QQ, Qin M, Li Lei*, Zhan YZ, He CL*. Facile synthesis of novel albumin-functionalized flower-like MoS2 nanoparticles for in vitro chemo-photothermal synergistic therapy. RSC Adv. 2016; 6:13040-13049.

7. Jia YT, Wang WZ, Zhou XJ, Nie W, Chen L, He CL*. Synthesis and characterization of poly(glycerol sebacate)-based elastomeric copolyesters for tissue engineering applications. Polym. Chem. 2016; 7: 2553-2564.

8. Qiu KX, Chen B, Nie W, Zhou XJ, Feng W, Wang WZ, Chen L, Mo XM, Wei YZ, He CL*. Electrophoretic deposition of dexamethasone-loaded mesoporous silica nanoparticles onto poly(L-lactic acid)/poly(ε–caprolactone) composite scaffold for bone tissue engineering. ACS Appl. Mater. Interfaces. 2016; 8 (6): 4137-4148.

9. Feng W, Chen L, Qin Ming, Zhou XJ, Zhang QQ, Miao YK, Qiu KX, Zhang YZ, He CL*. Flower-like PEGylated MoS2 nanoflakes for near-infrared photothermal cancer therapy. Scientific reports. 2015;5, 17422.

10. Zhou XJ, Chen L, Wang WZ, Jia YT, Chang AN, Mo XM, Wang HS, He CL*. Electrospun nanofibers incorporating self-decomposable silica nanoparticles as carriers for controlled delivery of anticancer drug. RSC Adv. 2015; 5: 65897-65904.

11. Feng W, Yin ZQ, Wang WZ, Chen L, Zhou XJ, Qiu KX, Zhou JF, Zhang YZ, He CL*. Synthesis and characterization of nanofibrous hollow microspheres with tunable size and morphology via thermally induced phase separation technique. RSC Adv. 2015; 5: 61580-61585.

12. Zhou XJ, Feng W, Qiu KX, Chen L, Wang WZ, Nie W, Mo XM, He CL*. BMP-2 derived peptide and dexamethasone incorporated mesoporous silica nanoparticles for enhanced osteogenic differentiation of bone mesenchymal stem cells. ACS Appl. Mater. Interfaces. 2015; 7 (29): 15777-15789.

13. Feng W, Zhou XJ, Nie W, Chen L, Qiu KX, Zhang YZ, He CL*. Au/polypyrrole@Fe3O4 nanocomposites for MR/CT dual-modal imaging guided-photothermal therapy: an in vitro study. ACS Appl. Mater. Interfaces. 2015; 7 (7): 4354-4367.

14. Feng W, Nie W, Cheng YH, Zhou XJ, Chen L, Qiu KX, Chen ZG*, Zhu MF, He CL*. In vitro and in vivo toxicity studies of copper sulfide nanoplates for potential photothermal applications. Nanomedicine: Nanotechnology, Biology and Medicine. 2015; 11(4): 901-912.

15. Wang WZ, Hu JW, He CL*, Nie W, Feng W, Qiu KX, Zhou XJ, Gao Yu, Wang GQ. Heparinized PLLA/PLCL nanofibrous scaffold for potential engineering of small diameter blood vessel: tunable elasticity and anticoagulation property. J. Biomed. Mater. Res., Part A. 2015; 103A (5):1784-1797.

16. He CL*, Nie W, Feng W. Engineering of biomimetic nanofibrous matrices for drug delivery and tissue engineering. J. Mater. Chem. B. 2014; 2(45):7828-7848. (cover paper)

17. Chen MX, Feng W, Lin S, Fan LP, He CL*, Gao Y, Wang HS*. Antitumor efficacy of a PLGA composite nanofiber embedded with doxorubicin@MSNs and hydroxycamptothecin@HANPs. RSC Adv. 2014; 4 (95): 53344-53351.

18. Zhou XJ, Cheng X, Feng W, Qiu KX, Chen L, Nie W, Yin ZQ, Mo XM, Wang HS, He CL*. Synthesis of hollow mesoporous silica nanoparticles with tunable shell thickness and pore size by using amphiphilic block copolymers as core templates. Dalton Trans. 2014; 43:11834-11842.

19. Feng W, Nie W, He CL*, Zhou XJ, Chen L, Qiu KX, Wang WZ, Yin ZQ. Effect of pH-responsive alginate/chitosan multilayers coating on delivery efficiency, cellular uptake and biodistribution of mesoporous silica nanoparticles based nanocarriers.  ACS Appl. Mater. Interfaces. 2014; 6 (11): 8447-8460.

20. He CL, Jin XB, Ma PX. Calcium phosphate deposition rate, structure and osteoconductivity on electrospun poly(l-lactic acid) matrix using electrodeposition or simulated body fluid incubation. Acta Biomater. 2014; 10(1): 419-427.

21. Feng W, Zhou XJ, He CL*, Qiu KX, Nie W, Chen L, Wang HS, Mo XM, Zhang YZ. Polyelectrolyte multilayer functionalized mesoporous silica nanoparticles for pH-responsive drug delivery: layer thickness-dependent release profiles and biocompatibility. J. Mater. Chem. B. 2013; 1(43):5886-5898. (cover paper)

22. Qiu KX, He CL*, Feng W, Wang WZ, Zhou XJ, Yin ZQ, Chen L, Wang HS, Mo XM. Doxorubicin-loaded electrospun poly(L-lactic acid)/mesoporous silica nanoparticles composite nanofibers for potential postsurgical cancer treatment. J. Mater. Chem. B. 2013; 1(36): 4601-4611.

23. He CL*, Zhang F, Cao LJ, Feng W, Zhang YZ, Wang HS, Mo XM, Wang JW. Rapid mineralization of porous gelatin scaffolds by electrodeposition for bone tissue engineering. J. Mater. Chem. 2012; 22(5): 2111-2119.

24. Fan LP, Wang HS*, Zhang KH, Cai ZX, He CL*, Sheng XY, Mo XM. Vitamin C-reinforcing silk fibroin nanofibrous matrices for skin care application. RSC Adv. 2012; 2: 4110-4119.

25. He CL*, Feng W, Cao LJ, Fan LP. Crosslinking of poly(L-lactide) nanofibers with triallyl isocyanutrate by gamma-irradiation for tissue engineering application. J. Biomed. Mater. Res., Part A. 2011; 99A (4): 655-665.

26. He CL*, Xu XH, Zhang F, Wang HS, Mo XM. Fabrication of fibrinogen/ P(LLA-CL) hybrid nanofibrous scaffold for potential soft tissue engineering applications. J. Biomed. Mater. Res., Part A. 2011; 97A (3): 339-347.

27. Zhang F, He CL*, Cao LJ, Feng W, Wang HS, Mo XM, Wang JW*. Fabrication of gelatin-hyaluronic acid hybrid scaffolds with tunable porous structures for soft tissue engineering. Int. J. Biol. Macromol. 2011; 48(3):474-481.

28.  He CL, Xiao GY, Jin XB, Sun CH, Ma PX. Electrodeposition on nanofibrous polymer scaffolds: rapid mineralization, tunable calcium phosphate composition and topography. Adv. Funct. Mater. 2010; 20(20):3568-3576.

29. He CL*, Huang ZM*, Han XJ. Fabrication of drug-loaded electrospun aligned fibrous threads for suture applications. J. Biomed. Mater. Res., Part A. 2009; 89A:80-95. 

代表性发明专利:

1. 何创龙,王伟忠,冯炜,周小军,尹郅祺。一种负载信号分子的三维组织工程纳米纤维支架及其制备方法。专利号:ZL2014101781682017/02.

2. 何创龙,冯炜,秦明,周小军,陈良。一种叶酸偶联的金纳米棒/聚吡咯/四氧化三铁多功能复合纳米诊疗剂的制备方法。专利号:ZL201410623958.62017/02.

3. 何创龙,贾亚听,王伟忠,冯炜,仇可新,周小军。一种生物医用多元共聚交联聚酯弹性体材料及其制备方法。专利号:ZL201510081762.32016/05.

4. 何创龙,王伟忠,仇可新,周小军,贾亚听。一种组织工程纳米纤维骨软骨修复支架及其制备方法。专利号:ZL201410582168.82016/04.

5. 何创龙,仇可新,周小军,冯炜,莫秀梅。一种聚合物基磷酸钙盐/胶原三维复合骨支架的制备方法。专利号:ZL201410177985.52015/09.

6. 何创龙,仇可新,王伟忠,冯炜,王红声,莫秀梅。一种利用电沉积技术制备微载体/聚合物复合支架的方法。专利号:ZL2013103118602015/01.

7. 何创龙,王伟忠,仇可新,冯炜。一种组织工程双层管状支架及其制备方法。专利号:ZL201310291723.72015/01.

8. 何创龙,程晓,胡金伟,仇可新,冯炜。一种中空介孔二氧化硅纳米粒子的制备方法。专利号:ZL201210253807.72014/01.

9. 何创龙,邱立军,徐晓红,王红声,莫秀梅。一种电沉积钙磷矿化层超细纤维骨材料的制备方法。专利号:ZL201210202165.12012/11.

国际交流与合作:

与美国The University of MichiganThe University of ChicagoWake Forest UniversityTexas A&M University和加拿大University of Manitoba等高校建立了学术联系,并派出学生进行博士生联合培养和从事博士后研究工作。

主讲课程:

组织工程(研究生课程)

生物材料学;组织工程;细胞工程(本科生课程)

招生信息:

欢迎具有生物、材料和化学等专业背景的学生报考硕、博士研究生或进行博士后合作研究。

联系电话:021-67792742;                                                                              Emailhcl@dhu.edu.cn