何创龙教授


何创龙,博士。东华大学生物工程系,教授,博士生导师。重庆大学生物医学工程专业博士学位,同济大学和密歇根大学(公派)博士后。近年来主持科技部、国家自然科学基金委、教育部、上海市科委和上海市教委等资助的科研项目20余项;发表期刊论文150多篇;发表国际会议论文摘要70多篇;出版译著一本;申请中国发明专利61项,获授权26项;系中国机械工程学会高级会员、美国化学会、中国化学会、中国生物材料学会、中国生物医学工程学会会员;担任110多个国际期刊的审稿人。



研究方向:

1. 生物材料与组织工程;

2. 生物墨水与生物制造;

3. 用于癌症诊断与治疗的生物纳米技术。


荣誉及获奖情况:

1. 香港桑麻基金会桑麻奖教金(2018年)

2. 第三届全国大学生生命科学创新创业大赛指导教师一等奖(2018年)

3. 上海市科学技术奖自然科学三等奖(2015年)


主要学术兼职:

1. 上海市生物医学工程学会生物材料专业委员会,副主任委员;

2. 中国医药教育协会医用生物材料与技术专业委员会,副主任委员;

3. 中国骨质疏松防治联盟,创始理事;

4. 中国机械工程学会生物制造工程分会,常务委员;

5. 中国解剖学会血管分会,常务委员;

6. 广东省医学生物力学重点实验室学术委员会,委员;

7. 中国医药生物技术协会3D打印技术分会,委员;

8. 上海市松江区分子影像专委会,委员。

主持的主要科研项目:

1. 国家重点研发计划课题(2018YFB1105602),细胞与基质材料一体化的组织适配性生物墨水及打印技术研发,2018.5-2021.4

2. 国家自然科学基金面上项目(31771048)诊疗一体化骨支架的仿生构建与骨再生的动态监测,2018.1-2021.12

3. 国家自然科学基金面上项目(31570984),促血管祖细胞募集的小口径血管支架构建与原位再生研究,2016.1-2019.12

4. 国家自然科学基金面上项目(31271028),双因子程序释放的骨支架构建及促血管化和成骨活性研究,2013.1-2016.12

5.教育部中央高校基本科研业务费学科交叉重点计划项目(2232018A3-07),基于多模态影像技术的可视化组织工程研究,2018.1-2020.12

6. 上海市科委国际科技合作项目(15540723400),石墨烯基纳米骨支架的构建及其在骨缺损治疗中的应用,2015.10-2018.9

7. 上海市教委科研创新重点项目(13ZZ051),外场作用下的电化学协同沉积与仿生骨支架研究,2013.1-2015.12

8. 上海市自然科学基金(11ZR1400100),纳米纤维的电化学协同自组装修饰及具有血管化潜能的骨支架研究,2011.4.1-2014.3.31

9. 上海市自然科学基金(07ZR14001),纤维蛋白纳米纤维组织工程血管的基础研究,2007.12-2009.11

10. 上海市科委纳米科技项目(11nm0505500),具有诱导血管生成和成骨活性的纳米纤维骨修复材料研究,2011.11-2014.9

11. 教育部留学回国人员科研启动基金,具有促血管化潜能的复合纳米纤维骨支架的研究,2012.1-2014.12

12. 教育部博士点基金(200802551014),纳米纤维的电化学仿生矿化及用于骨支架材料的研究,2009.1-2011.12

13. 上海市白玉兰科技人才基金(2010B001),有机/无机复合骨组织工程支架的研究,2010.6-2011.5


代表性学术论文:

1. Wang WZ, Nie W, Zhou XJ, Feng W, Chen L, Zhang QQ, You ZW, Shi QS*, Peng C*, He CL*. Fabrication of heterogeneous porous bilayered nanofibrous vascular grafts by two-step phase separation technique. Acta Biomater. 2018; 79: 168-181.

2. Zhang QQ, Qin M, Zhou XJ, Nie W, Wang WZ, Li L*, He CL*. Porous nanofibrous scaffold incorporated with S1P loaded mesoporous silica nanoparticles and BMP-2 encapsulated PLGA microspheres for enhancing angiogenesis and osteogenesis. J. Mater. Chem. B. 2018; 6(42): 6731-6743. (Inside front cover)

3. Nie W, Dai XY, Li DJ, Gillispie GJ, Zhang YZ, Yu BQ*, He CL*. One-pot synthesis of silver nanoparticle incorporated mesoporous silica granules for hemorrhage control and antibacterial treatment. ACS Biomater. Sci. Eng. 2018; 4: 3588-3599.

4. Wang WZ, Nie W, Liu DH, Du HB, Zhou XJ, Chen L, Whang HS, Mo XM, Li L*, He CL*. Macroporous nanofibrous vascular scaffold with improved biodegradability and smooth muscle cells infiltration prepared by dual phase separation technique. Int. J. Nanomed. 2018; 13: 7003-7018.

5. Li DJ, Nie W, Chen L, McCoul D, Liu DH, Zhang X, Ji Y, Yu BQ*, He CL*. Self-assembled hydroxyapatite-graphene scaffold for photothermal cancer therapy and bone regeneration. J. Biomed. Nanotechnol. 2018; 14: 2003-2017.

6. Zhou XJ, Wang WZ, Chen B, Feng W, Weng WZ, Zhang QQ, Nie W, Chen L, Mo XM, Su JC*, He CL*. Mesoporous silica nanoparticles/gelatin porous composite scaffolds with localized and sustained release of vancomycin for treatment of infected bone defects. J. Mater. Chem. B. 2018; 6: 740-752.

7. Wang WZ, Miao YK, Zhou XJ, Nie W, Chen L, Liu DH, Du HB, He CL*. Local delivery of BMP-2 from PLGA microspheres incorporated into porous nanofibrous scaffold for bone tissue regeneration. J. Biomed. Nanotechnol. 2017; 13(11): 1446-1456.

8. Chen L, Zhou XJ, Nie W, Feng W, Zhang QQ, Wang WZ, Zhang YZ, Chen ZG, Huang P*, He CL*. Marriage of albumin-gadolinium complexes and MoS2 nanoflakes as cancer theranostics for dual-modality magnetic resonance/photoacoustic imaging and photothermal therapy. ACS Appl. Mater. Interfaces. 2017; 9 (21):17786-17798.

9. Chen L, Feng YH, Zhou XJ, Zhang QQ, Nie W, Wang WZ, Zhang YZ, He CL*. One-pot synthesis of MoS2 nanoflakes with desirable degradability for photothermal cancer therapy. ACS Appl. Mater. Interfaces. 2017; 9 (20): 17347-17358.

10. Nie W, Peng C, Zhou XJ, Chen L, Wang WZ, Zhang YZ, Ma PX*, He CL*. Three-dimensional porous scaffold by self-assembly of reduced graphene oxide and nano-hydroxyapatite composites for bone tissue engineering. Carbon. 2017; 126: 325-337.

11. Wang WZ, Miao YK, Zhou XJ, Nie W, Chen L, Liu DH, Du HB, He CL*. Local delivery of BMP-2 from PLGA microspheres incorporated into porous nanofibrous scaffold for bone tissue regeneration. J. Biomed. Nanotechnol. 2017; 13: 1-11.

12.Chen L, Zhou XJ, Nie W, Zhang QQ, Wang WZ, Zhang YZ, He CL*. Multifunctional redox-responsive mesoporous silica nanoparticles for efficient targeting drug delivery and magnetic resonance imaging. ACS Appl. Mater. Interfaces. 2016, 8 (49): 33829-33841.

13. Zhou XJ, Chen L, Nie W, Wang WZ, Qin M, Mo XM, Wang HS, He CL*. Dual-responsive mesoporous silica nanoparticles mediated co-delivery of doxorubicin and Bcl-2 siRNA for targeted treatment of breast cancer. J. Phys. Chem. C. 2016; 120(39): 22375-22387.

14. Jia YT, Wang WZ, Zhou XJ, Nie W, Chen L, He CL*. Synthesis and characterization of poly(glycerol sebacate)-based elastomeric copolyesters for tissue engineering applications. Polym. Chem. 2016; 7: 2553-2564.

15. Qiu KX, Chen B, Nie W, Zhou XJ, Feng W, Wang WZ, Chen L, Mo XM, Wei YZ, He CL*. Electrophoretic deposition of dexamethasone-loaded mesoporous silica nanoparticles onto poly(L-lactic acid)/poly(ε–caprolactone) composite scaffold for bone tissue engineering. ACS Appl. Mater. Interfaces. 2016; 8 (6): 4137-4148.

16. Feng W, Chen L, Qin Ming, Zhou XJ, Zhang QQ, Miao YK, Qiu KX, Zhang YZ, He CL*. Flower-like PEGylated MoS2 nanoflakes for near-infrared photothermal cancer therapy. Sci. Rep.-UK. 2015;5:17422.

17. Zhou XJ, Feng W, Qiu KX, Chen L, Wang WZ, Nie W, Mo XM, He CL*. BMP-2 derived peptide and dexamethasone incorporated mesoporous silica nanoparticles for enhanced osteogenic differentiation of bone mesenchymal stem cells. ACS Appl. Mater. Interfaces. 2015; 7 (29): 15777-15789.

18. Feng W, Zhou XJ, Nie W, Chen L, Qiu KX, Zhang YZ, He CL*. Au/polypyrrole@Fe3O4 nanocomposites for MR/CT dual-modal imaging guided- photothermal therapy: an in vitro study. ACS Appl. Mater. Interfaces. 2015; 7(7): 4354-4367.

19. Feng W, Nie W, Cheng YH, Zhou XJ, Chen L, Qiu KX, Chen ZG*, Zhu MF, He CL*. In vitro and in vivo toxicity studies of copper sulfide nanoplates for potential photothermal applications. Nanomedicine: NBM. 2015; 11(4): 901-912.

20. He CL*, Nie W, Feng W. Engineering of biomimetic nanofibrous matrices for drug delivery and tissue engineering. J. Mater. Chem. B. 2014; 2(45): 7828-7848. (Front cover)

21. Zhou XJ, Cheng X, Feng W, Qiu KX, Chen L, Nie W, Yin ZQ, Mo XM, Wang HS, He CL*. Synthesis of hollow mesoporous silica nanoparticles with tunable shell thickness and pore size by using amphiphilic block copolymers as core templates. Dalton Trans. 2014; 43: 11834-11842.

22. Feng W, Nie W, He CL*, Zhou XJ, Chen L, Qiu KX, Wang WZ, Yin ZQ. Effect of pH-responsive alginate/chitosan multilayers coating on delivery efficiency, cellular uptake and biodistribution of mesoporous silica nanoparticles based nanocarriers.  ACS Appl. Mater. Interfaces. 2014; 6 (11): 8447-8460.

23. He CL, Jin XB, Ma PX. Calcium phosphate deposition rate, structure and osteoconductivity on electrospun poly(l-lactic acid) matrix using electrodeposition or simulated body fluid incubation. Acta Biomater. 2014; 10(1): 419-427.

24. Feng W, Zhou XJ, He CL*, Qiu KX, Nie W, Chen L, Wang HS, Mo XM, Zhang YZ. Polyelectrolyte multilayer functionalized mesoporous silica nanoparticles for pH-responsive drug delivery: layer thickness-dependent release profiles and biocompatibility. J. Mater. Chem. B. 2013; 1(43): 5886-5898.

25. Qiu KX, He CL*, Feng W, Wang WZ, Zhou XJ, Yin ZQ, Chen L, Wang HS, Mo XM. Doxorubicin-loaded electrospun poly(L-lactic acid)/mesoporous silica nanoparticles composite nanofibers for potential postsurgical cancer treatment. J. Mater. Chem. B. 2013; 1(36): 4601-4611.

26. He CL*, Zhang F, Cao LJ, Feng W, Zhang YZ, Wang HS, Mo XM, Wang JW. Rapid mineralization of porous gelatin scaffolds by electrodeposition for bone tissue engineering. J. Mater. Chem. 2012; 22(5): 2111-2119.

27. Zhang F, He CL*, Cao LJ, Feng W, Wang HS, Mo XM, Wang JW. Fabrication of gelatin-hyaluronic acid hybrid scaffolds with tunable porous structures for soft tissue engineering. Int. J. Biol. Macromol. 2011; 48(3): 474-481.

28. He CL*, Feng W, Cao LJ, Fan LP. Crosslinking of poly(L-lactide) nanofibers with triallyl isocyanutrate by gamma-irradiation for tissue engineering application. J. Biomed. Mater. Res., Part A. 2011; 99A (4): 655-665.

29. He CL*, Xu XH, Zhang F, Wang HS, Mo XM. Fabrication of fibrinogen/ P(LLA-CL) hybrid nanofibrous scaffold for potential soft tissue engineering applications. J. Biomed. Mater. Res., Part A. 2011; 97A (3): 339-347.

30. He CL, Xiao GY, Jin XB, Sun CH, Ma PX. Electrodeposition on nanofibrous polymer scaffolds: rapid mineralization, tunable calcium phosphate composition and topography. Adv. Funct. Mater. 2010; 20(20):3568-3576.


主讲课程:

高级组织工程学(博士生);组织工程(硕士生)

生物材料学(本科生)


招生信息:

欢迎具有生物、材料和化学等专业背景的学生报考硕、博士研究生或进行博士后合作研究。


联系电话:021-67792742;                                                                 Emailhcl@dhu.edu.cn