陆昌瑞

时间:2015-03-09发布部门:人员机构


陆昌瑞教授



1983年6月出生。美国科尔盖特大学(Colgate University)全额奖学金分子生物学学士(2005),美国康奈尔大学(Cornell University)生命科学研究生院生物化学、生物物理学博士(2011),美国密西根大学(University of Michigan)医学院博士后,2012年6月被东华大学评定为教授。




研究方向:

核开关三维结构与机理 X-ray晶体结构、RNA调节因子发现、功能和机理。

主要研究成果:

从事RNA的结构与功能、基因的表达与调控等研究:核开关和其他非编码RNA 的结构、机理和功能;Packaging RNA (pRNA)的晶体结构与复合体的包装机理;外切体复合物的晶体结构与机理;昆虫胚胎耐冻性的分子机理,其成果发表于Nature SMB、PNAS、Journal of Molecular Biology等国际著名杂志。

近几年发表的论著作

1、Ding F,Lu Changrui et al. Structure and assembly of the essential RNA ring component of a viral DNA packaging motor. PNAS.2011

2、Lu Changrui, Ding F, Ke A. Folding of the SAM-III/SMK box riboswitch is hypersensitive to sequences outside the SAM-binding core. Journal of Molecular Biology2011

3、Lu Changruiet al. SAM Recognition and Conformational Switching Mechanism in the Bacillus subtilis yitJ SBox/SAM-I Riboswitch. Journal of Molecular Biology2010

4、Lu Changrui, Ding F, Ke A. Crystal structure of the S. solfataricusarchaeal exosome reveals conformational flexibility in the RNA-binding ring. PLoS ONE2010

5、Lu Changruiet al. Crystal Structures of the SMK box (SAM-III) Riboswitch Reveal the SAM-dependent Translation Inhibition Mechanism. Nature SMB. 2008

6、Pruitt NL, Changrui Lu.Seasonal changes in phospholipid class and class-specific fatty acid composition associated with the onset of freeze tolerance in third-instar larvae of Eurosta solidaginis. Physiological and biochemical zoology. 2008

7、Perreira M, Jiang JK, Klutz AM, Gao ZG, Shainberg A, Changrui Lu, Thomas CJ, Jacobson KA.“Reversine” and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. Journal of medicinal chemistry. 2005

8、Jeong LS, Lee HW, Jacobson KA, Kim HO, Shin DH, Lee JA, Gao ZG, Changrui Lu, Duong HT, Gunaga P, Lee SK, Jin DZ, Chun MW, Moon HR. Structure-activity relationships of 2-chloro-N6-substituted-4‘-thioadenosine-5’-uronamides as highly potent and selective agonists at the human A3 adenosine receptor. J Med Chem. 2006

9、Cosyn L, Gao ZG, Van Rompaey P, Changrui Lu, Jacobson KA, Van Calenbergh S. Synthesis of hypermodified adenosine derivatives as selective adenosine A3 receptor ligands. Bioorg Med Chem. 2006

其他信息:

课题组长期招收具有细胞与分子生物学、计算生物学、生物化学业等相关研究背景的硕、博士研究生和博士后研究人员。有意者请email至crlu@dhu.edu.cn

联系电话:021-67792740          EMAIL:crlu@dhu.edu.cn


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