陈志龙

时间:2015-03-09发布部门:人事处

陈志龙教授

陈志龙,男,196812月生;为第二军医大学药学学士、药物化学博士,曾先后在中科院上海有机化学研究所、澳大利亚Central Queensland University、英国The University of Liverpool进行博士后研究。曾任第二军医大学防护医学教研室主任、学科带头人。现为东华大学化学化工与生物工程学院生物医药研究组课题组长,PI,药物化学与药理学教授,博士生导师。

为中国光学会激光医学分会常务理事;上海生化药物专业委员会副主任委员;上海药物化学专业委员会委员;国家科学技术奖励评审专家;科技部重大重点专项评审专家;国家自然科学基金评审专家;教育部计划项目与博士点基金评审专家;上海市科委项目评审专家。

发表论文200余篇。出版中英文专著4部。申请国家发明专利70余项。

研究方向:

1)光动力新药研发及光动力疗法的基础与应用研究(如抗肿瘤、抗鲜红斑痣、抗类风湿性关节炎、抗病毒作用等);

2)分子靶向药物研究(如血管紧张素受体拮抗剂类新药的设计、合成及其降压、抗心衰、预防老年痴呆及抗肿瘤作用研究;叶酸、多肽等靶向分子导向的新药研究);

3)药物纳米靶向载体研究(如磁靶向药物纳米载体与纳米传递系统研究);

4)天然活性产物及中药现代化研究;

5)转化医学研究。

主要研究成果:

1)在光动力新药研制及光动力疗法基础与应用研究领域做出了出色成绩,在国内外有一定影响力。有2个光动力新药进入临床研究。

2)创制了多个高效、长效、低毒的沙坦类降压新药,正在进行临床前研究;

3)作为主要成员参与研发的国家一类抗肿瘤新药CM-Na已获准上市,该项目获国家发明二等奖。

4)发现了一个新的有机化学反应--三联吡啶的重排反应,该反应在制备具有特殊光化学与光生物医学性能的三联吡啶化合物及其金属配合物领域具有重要用途。

5)在纳米靶向传递系统研究领域,在新药药理评价模型构建、新药评价方法研究等领域也做出了一定成绩。

6)在新药仿制与医药中间体制备工艺研究领域做出了出色成绩。茶碱类系列产品、氨基葡萄糖系列产品在企业实现产业化,产值过亿元。

荣誉及获奖情况:

1、第二军医大学 “学习成才十佳先进个人” (2001)

2、上海市浦江人才(2006);

3、南京市创新创业人才(2012);

4、上海市优秀学术技术带头人2015年)

5、主持项目光敏新药与试剂的研制及光动力疗法的基础与应用研究2012年上海市药学科技二等奖。

6、主持项目光敏新药与试剂的研制及光动力疗法的基础与应用研究2013年中国药学科技三等奖。

7、参与项目(第二负责人)光动力治疗皮肤病关键技术创新及推广应用2017年中华医学科技三等奖。

承担的项目:

承担各类项目70余项,其中主持50余项,参与20余项。如主持国家自然科学基金5项、军队医药卫生重大课题1项、上海市科委与教委重点项目6项、国际合作项目5项等。参与国家与国际重要课题6项,如国家新药创制重大专项、国家自然科学基金重点项目等;指导团队成员获国家自然基金5项、国家与上海市博士后基金10项等。部分课题如下:

1、国家自然科学基金5项(编号:2137204230973611302715343007086229872055)。

2、上海市优秀学术技术带头人人才计划基金(编号:15XD1523400)。

3、上海市浦江人才计划基金(编号:06PJ14001)。

4、国家科技部国际合作基金(编号:6-11)。

5、上海市科委重大重点基金(编号:174319026001541196040015431904100141409035001343190070006431902010DZ05023001052nm049001543190410014431906200等)。

6、上海市科委国际科技合作基金(编号:1843071300017430741800174307119001343072230011BA1400700)。

8、军队医药卫生重大项目(编号01L054)。

9、上海市教委重点项目基金(编号:10ZZ45)。

发表论文:发表论文200余篇,其中近4年发表SCI论文40余篇。部分论文如下:

1.Xiaolu Bao, Weibo Zhu, Zhilong Chen*, et al. Design, synthesis and evaluation of novel potent angiotensin II receptor 1 antagonists. European Journal of Medicinal Chemistry, 2016, 123,115-127.

2.Weibo Zhu, Xiaolu Bao, Zhilong Chen*, et al. N-phenyl indole derivatives as AT1 antagonists with anti-hypertension activities: design, synthesis and biological evaluation. European Journal of Medicinal Chemistry, 2016, 115,161-178.

3.Hongyu Tan, Ioannis Houpis, Zhilong Chen*, et al. Olefin preparation via palladium-catalyzed oxidative de-azotative and de-sulfitative internal cross-coupling of sulfonylhydrazones. Organic Letters, 2015,17(14)3548-3551.

4.Dan Wu, Shane Cheung, Zhi-Long Chen and Donal F. O’Shea, et al. Synthesis and assessment of a maleimide functionalized BF2 azadipyrromethene near-infrared fluorochrome. Chemical Communications, 2015, 51(93), 16667-16670.

5.Ping-Yong Liao, Xin-Rong Wang, Zhi-Long Chen*, et al. Synthesis of 2-morpholinetetraphenylporphyrins and their photodynamic activities. Bioorganic Chemistry, 2017, 71: 299 - 304.

6.Li Wang, Wei Zhu, Zhi-Long Chen*, et al. Preparation of a chlorophyll derivative and investigation of its photodynamic activities against cholangiocarcinoma. Biomedicine & Pharmacotherapy. 2017, 92: 285-292.

7.Lei-Lei Bao, Donal F. O’Shea*, Zhi-Long Chen*, et al. In vitro and in vivo evaluation of a pyropheophorbide-a derivative as a potential photosensitizer for age-related macular degeneration. Biomedicine & Pharmacotherapy, 2017, 88: 1220-1226.

8.Zhongqi Xu, Zhilong Chen, Takeshi Hirokawa, et al. Pressure-assisted electrokinetic injection stacking for verteporfin drug to achieve highly sensitive enantioseparation and detectionin artificial urine by capillary electrophoresis. Journal of Chromatography A, 2014, 1355: 284-290.

9.Hongyu Tan, Ioannis Houpis*, Zhilong Chen*, et al. Palladium-catalyzed coupling of sulfonylhydrazones with heteroaromatic 2-amino-halides (Barluenga Reaction): exploring the electronics of the sulfonylhydrazone. Organic Process Research & Development. 2015, 19(8), 1044-1048.

10.Xiang-Hua Zhang, Li-Jun Zhang, Zhi-Long Chen*, et al. Photodynamic efficiency of a chlorophyll-a derivative in vitro and in vivo. Biomedicine & Pharmacotherapy, 2016, 81, 265-272.

11.Li-Jun Zhang, Donal O’Shea, Zhi-Long Chen*, et al. Evaluation of a bacteriochlorin-based photosensitizer’s anti-tumor effect in vitro and in vivo. Journal of Cancer Research and Clinical Oncology, 2015, 14111: 1921-1930.

12.Li-Jun Zhang, Jun Bian, Zhi-Long Chen*, et al. Photosensitizing effectiveness of a novel chlorin-based photosensitizer for photodynamic therapy in vitro and in vivo. Journal of Cancer Research and Clinical Oncology, 2014, 140(9): 1527-1536.

13.Li-Jun Zhang, Yi-Jia Yan, Zhi-Long Chen*, et al. Antitumor activity evaluation of meso-tetra (pyrrolidine substituted) pentylporphin-mediated photodynamic therapy in vitro and in vivo. Journal of Photochemistry & Photobiology, B: Biology. 2016, 163:224-231.

14.Ping-Yong Liao, Ying-Hua Gao, Zhi-Long Chen*, et al. Tetraphenylporphyrin derivatives possessing piperidine group as potential agents for photodynamic therapy. Journal of Photochemistry & Photobiology, B: Biology. 2016, 165: 213-219.

15.Xiao-Lu Bao,  Wei-Bo Zhu, Zhi-Long Chen*, et al. Design, synthesis and evaluation of novel angiotensin II receptor 1 antagonists with antihypertensive activities. RSC Adv., 2017, 7: 26401-26410.

16.Pingyong Liao, Yijia Yan, and Zhilong Chen*, et al. Synthesis, characterization and biological evaluation of a novel biscarboxymethyl-modified tetraphenylchlorin compound for photodynamic therapy. RSC Advances, 2016, 6: 26186-26191.

17.Mengshi Yang, Di Jiang, Zhilong Chen and Jun Chen, Photodynamic therapy of drug-resistant human colon adenocarcinoma using verteporfin loaded TPGS nanoparticle with tumor homing and penetrating peptide functionalized. RSC Advances, 2016, 6: 100984-100992.

18.Dan Wu, Shane Cheung, Zhi-long Chen, and Donal F. O'Shea. Strained alkyne substituted near infrared BF2 azadipyrromethene fluorochrome. RSC Advances, 2016, 6: 87373-87379.

19.Li-Jun Zhang, Davor Margetic, Zhi-Long Chen*, et al. Synthesis and antitumor activity evaluation of a novel porphyrin derivative for photodynamic therapy in vitro and in vivo. Tumor Biology, 2016, 376923-6933.

20.Lai-Xing Wang, Donal O’Shea, Zhi-Long Chen*, et al. Antitumor activity of photodynamic therapy with a chlorin derivative in vitro and in vivo. Tumor Biology, 2015, 36(9):6839-6847.

21. Jian-Wei Li, Davor Margetic, Zhi-Long Chen*, et al. Antitumor effects evaluation of a novel porphyrin derivative in photodynamic therapy. Tumor Biology, 2015, 36(12): 9685-9692.

22.Sonja Srdanovic, Ying-Hua Gao, Davor Margetic*, Zhi-Long Chen*. The photodynamic activity of 131-[2’-(2-pyridyl)ethylamine] chlorin e6 photosensitizer in human esophageal cancer. Bioorganic & Medicinal Chemistry Letters. 2018, 28(10): 1785-1791.

23.Wei Zhu, Yi-Jia Yan, Zhi-Long Chen*, et al. Synthesis and biological evaluation of 173-dicarboxylethyl pyropheophorbide-a amide derivatives for photodynamic therapy. Bioorganic & Medicinal Chemistry Letters. 2018, 28: 2784-2788.

24.Yi-Jia Yan,Li-Jun Zhang,Zhi-Long Chen*, et al. Inhibition of laser-induced choroidal neovascularization by hematoporphyrin dimethylether-mediated photodynamic therapy in rats. Biol. Pharm. Bull. 2017, 40(12): 2088-2095.

25.Wei Zhu, Ying-Hua Gao, Zhi-Long Chen*, et al. Synthesis and evaluation of new 5-aminolevulinic acid derivatives as prodrugs of protoporphyrin for photodynamic therapy. Photochemical & Photobiological Sciences. 2017, 16: 1623-1630.

26.Ping-Yong Liao, Xinrong Wang, Zhi-Long Chen*, et al. Synthesis, photophysical properties and biological evaluation of b-alkylaminoporphyrin for photodynamic therapy. Bioorganic & Medicinal Chemistry, 2016, 2422, 6040-6047. 

27.Xiaolu Bao, Weibo Zhu, Zhilong Chen*, et al. Synthesis and evaluation of novel angiotensin II receptor 1 antagonists as anti-hypertension drugs. Bioorganic & Medicinal Chemistry, 2016, 24(9):2023-2031.

28.Weibo Zhu, Yajing Da,Dan Wu, Zhilong Chen*, et al. Design, synthesis and biological evaluation of new 5-nitro benzimidazole derivatives as AT1 antagonists with anti-hypertension activities. Bioorganic & Medicinal Chemistry. 2014, 22(7): 2294-2302. 

29.Hongyu Tan, Ioannis Houpis*, Zhilong Chen*, et al. Olefin synthesis by the Pd-catalyzed cross coupling on sulfonylhydrazones with aromatic sulfinates.  Tetrahedron Letters, 2016, 57(21): 2336-2340.

30.Zhang Chunye, Zhang Lijun,  Chen Zhilong*, et al. In vitro and in vivo antitumor activity of a novel chlorin derivative for photodynamic therapy. Neoplasma. 2016, 63(1): 37-43.

31.Weibo Zhu, Xiaolu Bao, Zhilong Chen*, et al. Design, synthesis and pharmacological evaluation of 5-oxo-1,2,4-oxadiazole derivatives as AT1 antagonists with anti-hypertension activities. Clinical and Expermental Hypertension. 2016, 38(5): 435-442.

32.Anamarija B., Zeljko M., Zhi-Long Chen, Davor M. Synthesis of chlorins by Diels–Alder cycloadditions of pheophorbide a and its derivatives, Synlett. 2015, 26 (07): 991-994.

33.Xiaolu Bao, Weibo Zhu, Zhilong Chen*, et al. Synthesis and pharmacological evaluation of a novel AT1 angiotensin II receptor antagonist with anti-hypertension and anti-tumor effects. Clinical and Expermental Hypertension. 2015, 37(6): 490-497.

34.Yun Sun, Zhi-Long Chen*, et al. Magnetic chitosan nanoparticles as drug delivery system for targeting photodynamic therapy. Nanotechnology, 2009, 20 (13): 135102 (8 pp).

35.Zhi-Long Chen*, Yun Sun, et al. Studies on preparation of photosensitizer loaded magnetic silica nanoparticles and their antitumor effects for targeting photodynamic therapy, Nanoscale Research Letters, 2009, 4, 400-408


国际交流与合作:

与英国利物浦大学、爱尔兰都柏林大学、爱尔兰皇家外科学院、美国华盛顿州立大学、澳大利亚中昆士兰大学、克罗地亚鲁德尔博斯科维奇研究所等多所大学与研究所有合作关系。

讲授课程:

新药研究开发学、新药研发导论、基础有机化学实验

研究团队:

团队成员30余名,含有机化学博士助手1名,药理学博士助手1名,化学与生物医学博士后2名,博士硕士研究生二十余名。

博士后招聘:

招收药学、化学、生物学、基础医学、预防医学、材料学等专业博士后。

博士、硕士研究生招生:

在有机化学、生物化学与分子生物学、生物化工、生物医学工程、材料学等专业的博士、硕士点,招收药学、化学、生物学、医学、材料学、纺织科学等专业背景研究生。

就业前景:

本课题组研究方向就业前景好。

电话:021-67792654                                                                               E-mailzhlchen@dhu.edu.cn


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信息员:刁婧
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