郭睿教授



郭睿,198012月生,化学化工与生物工程学院教授。2008年毕业于南京大学,2015-2016年美国密歇根大学医学院访学一年。主要从事纳米材料在生物医药领域的应用基础研究,构建了多种无机/高分子靶向纳米药物输送体系,推进肿瘤的个体化与精准治疗;构建了具有肿瘤多模态成像与联合治疗功能的纳米平台用于肿瘤的可视化治疗。已发表SCI学术期刊论文80余篇,获授权专利7项。论文主要发表在SmallTheranosticsJ. Mater. Chem. B等国际主流专业期刊上。


研究方向:

1、高分子纳米药物输送体系的制备与抗肿瘤效果评价。

2、有机/无机纳米复合材料的合成及其在肿瘤诊疗中的应用。

3、静电纺纳米纤维材料在生物医学与环境科学中的应用。

近年来承担的主要科研项目:

1上海市人才发展资金项目(2019115),2019/09-2022/09

2、国家自然科学基金委员会自然科学基金面上项目(21875031),基于超分子主客体组装构建的核-壳结构树状大分子纳米平台用于肿瘤靶向的多模态成像与协同治疗,2019/01-2022/12

3、上海市科学技术委员会自然科学基金项目(17ZR1401200),锂皂石-聚多巴胺杂化纳米载体的设计及其肿瘤靶向诊疗研究,2017/05-2020/04

4、国家自然科学基金青年项目(81201189),基于纳米锂皂石的药物输送体系用于乳腺癌的靶向化疗,2013/01-2015/12

近年来发表的代表性论著、专利:

论文

1Liu, R.; Xu, F.; Wang, L.; Liu, M.; Cao, X.; Shi, X.*; Guo, R.*, Polydopamine-Coated Laponite Nanoplatforms for Photoacoustic Imaging-Guided Chemo-Phototherapy of Breast Cancer. Nanomaterials 2021, 11, 394.

2Liu, R.; Guo, H.; Ouyang, Z.; Fan, Y.; Cao, X.; Xia, J.; Shi, X.*; Guo, R.*, Multifunctional Core–Shell Tecto Dendrimers Incorporated with Gold Nanoparticles for Targeted Dual Mode CT/MR Imaging of Tumors. ACS Applied Bio Materials2021, 4, 1803-1812.

3Zhang, N.; Wang, Y.; Zhang, C.; Fan, Y.; Li, D.; Cao, X.; Xia, J.; Shi, X.; Guo, R.*, LDH-Stabilized Ultrasmall Iron Oxide Nanoparticles as a Platform for Hyaluronidase-Promoted Mr Imaging and Chemotherapy of Tumors. Theranostics 2020, 10, 2791-2802.

4Wu, Y.; Li, K.; Kong, L.; Tang, Y.; Li, G.; Jiang, W.; Shen, M.; Guo, R.*; Zhao, Q.*; Shi, X.*, Functional Laponite Nanodisks Enable Targeted Anticancer Chemotherapy in Vivo. Bioconjugate Chemistry2020, 31, 2404-2412.

5Ding, L.; Wang, R.; Hu, Y.; Xu, F.; Zhang, N.; Cao, X.; Wang, X.; Shi, X.; Guo, R.*, Folic Acid-Modified Laponite (R)-Stabilized Fe3O4 Nanoparticles for Targeted T2-Weighted MR Imaging of Tumor. Applied Clay Science2020, 186, 105447.

6Liu, M.; Zhang, J.; Li, X.; Cai, C.; Cao, X.; Shi, X.*; Guo, R.*, A Polydopamine-Coated Laponites-Stabilized Iron Oxide Nanoplatform for Targeted Multimodal Imaging- Guided Photothermal Cancer Therapy. Journal of Materials Chemistry B2019, 7, 3856-3864.

7Xu, F.; Liu, M.; Li, X.; Xiong, Z.; Cao, X.; Shi, X.*; Guo, R.*, Loading of Indocyanine Green within Polydopamine-Coated Laponite Nanodisks for Targeted Cancer Photothermal and Photodynamic Therapy. Nanomaterials 2018, 8, 347.

8Zhuang, Y.; Zhou, L.; Zheng, L.; Hu, Y.; Ding, L.; Li, X.; Liu, C.; Zhao, J.; Shi, X.*;Guo, R.*, Laponite-Polyethylenimine Based Theranostic Nanoplatform for Tumor-Targeting Ct Imaging and Chemotherapy. ACS Biomaterials Science & Engineering2017, 3, 431-442.

9Qi, R.; Tian, X.; Guo, R.*; Luo, Y.; Shen, M.-w.; Yu, J.; Shi, X.*., Controlled Release of Doxorubicin from Electrospun MWCNTs/PLGA Hybrid Nanofibers. Chinese Journal of Polymer Science2016, 34, 1047-1059.

10Ding, L.; Hu, Y.; Luo, Y.; Zhu, J.; Wu, Y.; Yu, Z.; Cao, X.; Peng, C.*; Shi, X.*; Guo, R.*, Laponite (R)-Stabilized Iron Oxide Nanoparticles for in Vivo Mr Imaging of Tumors. Biomaterials Science 2016, 4, 474-482.

11Mustafa, R.; Luo, Y.; Wu, Y.; Guo, R.*; Shi, X.*, Dendrimer-Functionalized Laponite Nanodisks as a Platform for Anticancer Drug Delivery. Nanomaterials2015, 5, 1716-1731.

12Chen, G.; Li, D.; Li, J.; Cao, X.; Wang, J.*; Shi, X.*; Guo, R.*, Targeted Doxorubicin Delivery to Hepatocarcinoma Cells by Lactobionic Acid-Modified Laponite Nanodisks. New Journal of Chemistry2015, 39, 2847-2855.

专利

1郭睿,徐凡丽。一种负载吲哚菁绿的锂皂石纳米颗粒ICG/LAP的制备方法,中国发明专利,专利号:ZL 201710308789.0

2、郭睿,庄英。一种负载阿霉素的聚乙烯亚胺-透明质酸修饰的锂皂石包裹金纳米颗粒的制备方法,中国发明专利,专利号:ZL 201610292982.5

国际交流与合作:

美国密歇根大学(University of Michigan, Ann Arbor),匈牙利徳布勒森大学(University of Debrecen),波兰罗兹大学(University of Lodz)。

联系电话:021-67792750                                 E-MAILruiguo@dhu.edu.cn